6E9A

HIV-1 WILD TYPE PROTEASE WITH GRL-034-17A, (3aS, 5R, 6aR)-2-OXOHEXAHYD CYCLOPENTA[D]-5-OXAZOLYL URETHANE WITH A BICYCLIC OXAZOLIDINONE SCAFF AS THE P2 LIGAND

Summary for 6E9A

Entry DOI	10.2210/pdb6e9a/pdb
Related	2IEN 6E7J
Descriptor	Protease, SODIUM ION, CHLORIDE ION, ... (6 entities in total)
Functional Keywords	antiviral, hiv-1 protease inhibitor of grl-034-17a, p2 ligand, multidrug-resistant, oxazolidinone, viral protein, hydrolase-hydrolase inhibitor complex, hydrolase, hydrolase/hydrolase inhibitor
Biological source	Human immunodeficiency virus 1
Total number of polymer chains	2
Total formula weight	22219.94
Authors	Wang, Y.-F.,Agniswamy, J.,Weber, I.T. (deposition date: 2018-07-31, release date: 2018-11-07, Last modification date: 2023-10-11)
Primary citation	Ghosh, A.K.,Williams, J.N.,Ho, R.Y.,Simpson, H.M.,Hattori, S.I.,Hayashi, H.,Agniswamy, J.,Wang, Y.F.,Weber, I.T.,Mitsuya, H. Design and Synthesis of Potent HIV-1 Protease Inhibitors Containing Bicyclic Oxazolidinone Scaffold as the P2 Ligands: Structure-Activity Studies and Biological and X-ray Structural Studies. J. Med. Chem., 61:9722-9737, 2018 Cited by PubMed: 30354121 DOI: 10.1021/acs.jmedchem.8b01227 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.22 Å)

Structure validation