Structure of the Mango-III (A10U) aptamer bound to TO1-Biotin

Summary for 6E8T

DescriptorRNA (35-MER), 1-methyl-4-{[3-(2-oxopropyl)-1,3-benzothiazol-3-ium-2-yl]methyl}quinolin-1-ium, POTASSIUM ION, ... (5 entities in total)
Functional Keywordsaptamer, fluorescence, rna, g-quadruplex
Biological sourcesynthetic construct
Total number of polymer chains4
Total molecular weight48172.82
Trachman, R.J.,Ferre-D'Amare, A.R. (deposition date: 2018-07-31, release date: 2019-04-17, Last modification date: 2019-04-24)
Primary citation
Trachman 3rd., R.J.,Autour, A.,Jeng, S.C.Y.,Abdolahzadeh, A.,Andreoni, A.,Cojocaru, R.,Garipov, R.,Dolgosheina, E.V.,Knutson, J.R.,Ryckelynck, M.,Unrau, P.J.,Ferre-D'Amare, A.R.
Structure and functional reselection of the Mango-III fluorogenic RNA aptamer.
Nat. Chem. Biol., 15:472-479, 2019
PubMed: 30992561 (PDB entries with the same primary citation)
DOI: 10.1038/s41589-019-0267-9
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRSRZ outliersRNA backbone 0.237100 0.36MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6e8t
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Molmil generated image of 6e8t
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Molmil generated image of 6e8t
rotated about y axis by 90°