6E5G

Crystal structure of human TEAD2-Yap binding domain covalently bound to an allosteric regulator

6E5G の概要

• エントリーDOI: 10.2210/pdb6e5g/pdb
• 分子名称: Transcriptional enhancer factor TEF-4, 1-(2-{[3-(trifluoromethyl)phenyl]amino}phenyl)ethan-1-one (3 entities in total)
• 機能のキーワード: inhibitor, transcription-inhibitor complex, transcription/inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 53987.01

構造登録者

Bum-Erdene, K.,Gonzalez-Gutierrez, G.,Meroueh, S.O. (登録日: 2018-07-20, 公開日: 2019-01-09, 最終更新日: 2023-10-11)

• 主引用文献: Bum-Erdene, K.,Zhou, D.,Gonzalez-Gutierrez, G.,Ghozayel, M.K.,Si, Y.,Xu, D.,Shannon, H.E.,Bailey, B.J.,Corson, T.W.,Pollok, K.E.,Wells, C.D.,Meroueh, S.O.; Small-Molecule Covalent Modification of Conserved Cysteine Leads to Allosteric Inhibition of the TEAD⋅Yap Protein-Protein Interaction.; Cell Chem Biol, 26:378-, 2019; PubMed: 30581134; DOI: 10.1016/j.chembiol.2018.11.010

実験手法

X-RAY DIFFRACTION (2.43 Å)