6E53

Structure of TERT in complex with a novel telomerase inhibitor

6E53 の概要

• エントリーDOI: 10.2210/pdb6e53/pdb
• 分子名称: Telomerase reverse transcriptase, RNA/DNA hairpin, MAGNESIUM ION, ... (4 entities in total)
• 機能のキーワード: telomerase, catalytic subunit, telomerase inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Tribolium castaneum (red flour beetle); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 78333.05

構造登録者

Hernandez-Sanchez, W.,Huang, W.,Plucinsky, B.,Garcia-Vazquez, N.,Berdis, A.J.,Skordalakes, E.,Taylor, D.J. (登録日: 2018-07-19, 公開日: 2019-03-27, 最終更新日: 2023-10-11)

• 主引用文献: Hernandez-Sanchez, W.,Huang, W.,Plucinsky, B.,Garcia-Vazquez, N.,Robinson, N.J.,Schiemann, W.P.,Berdis, A.J.,Skordalakes, E.,Taylor, D.J.; A non-natural nucleotide uses a specific pocket to selectively inhibit telomerase activity.; Plos Biol., 17:e3000204-e3000204, 2019; PubMed: 30951520; DOI: 10.1371/journal.pbio.3000204

実験手法

X-RAY DIFFRACTION (2.8 Å)