6E4E

Crystal structure of dihydrofolate reductase from Staphylococcus aureus MW2 bound to NADP and p218

Summary for 6E4E

• Entry DOI: 10.2210/pdb6e4e/pdb
• Descriptor: Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)propanoic acid, ... (4 entities in total)
• Functional Keywords: niaid, dhfr, folate, folic acid, mmv, inhibitor, malaria, structural genomics, seattle structural genomics center for infectious disease, ssgcid, oxidoreductase, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
• Biological source: Staphylococcus aureus
• Total number of polymer chains: 1
• Total formula weight: 21840.47

Authors

Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2018-07-17, release date: 2018-07-25, Last modification date: 2023-10-11)

• Primary citation: Edwards, T.E.,Mayclin, S.J.,Lorimer, D.D.,Horanyi, P.S.,Seattle Structural Genomics Center for Infectious Disease (SSGCID); Crystal structure of dihydrofolate reductase from Staphylococcus aureus MW2 bound to NADP and p218; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.9 Å)