6E4E
Crystal structure of dihydrofolate reductase from Staphylococcus aureus MW2 bound to NADP and p218
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Dihydrofolate reductase | polymer | 182 | 20736.7 | 1 | UniProt (P0A017) Pfam (PF00186) | Staphylococcus aureus | DHFR |
| 2 | B (A) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 1 | Chemie (NAP) | |||
| 3 | C (A) | 3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)propanoic acid | non-polymer | 360.4 | 1 | Chemie (MMV) | |||
| 4 | D (A) | water | water | 18.0 | 117 | Chemie (HOH) |
Sequence modifications
A: 0 - 158 (UniProt: P0A017)
| PDB | External Database | Details |
|---|---|---|
| Met -23 | - | initiating methionine |
| Gly -22 | - | expression tag |
| Ser -21 | - | expression tag |
| Ser -20 | - | expression tag |
| His -19 | - | expression tag |
| His -18 | - | expression tag |
| His -17 | - | expression tag |
| His -16 | - | expression tag |
| His -15 | - | expression tag |
| His -14 | - | expression tag |
| Ser -13 | - | expression tag |
| Ser -12 | - | expression tag |
| Gly -11 | - | expression tag |
| Leu -10 | - | expression tag |
| Val -9 | - | expression tag |
| Pro -8 | - | expression tag |
| Arg -7 | - | expression tag |
| Gly -6 | - | expression tag |
| Ser -5 | - | expression tag |
| His -4 | - | expression tag |
| Met -3 | - | expression tag |
| Ala -2 | - | expression tag |
| Ser -1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 20736.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1103.8 | |
| All* | Total formula weight | 21840.5 |
