6E4E
Crystal structure of dihydrofolate reductase from Staphylococcus aureus MW2 bound to NADP and p218
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Dihydrofolate reductase | polymer | 182 | 20736.7 | 1 | UniProt (P0A017) Pfam (PF00186) In PDB | Staphylococcus aureus | DHFR |
2 | A | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 1 | Chemie (NAP) | |||
3 | A | 3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)propanoic acid | non-polymer | 360.4 | 1 | Chemie (MMV) | |||
4 | water | water | 18.0 | 117 | Chemie (HOH) |
Sequence modifications
A: 0 - 158 (UniProt: P0A017)
PDB | External Database | Details |
---|---|---|
Met -23 | - | initiating methionine |
Gly -22 | - | expression tag |
Ser -21 | - | expression tag |
Ser -20 | - | expression tag |
His -19 | - | expression tag |
His -18 | - | expression tag |
His -17 | - | expression tag |
His -16 | - | expression tag |
His -15 | - | expression tag |
His -14 | - | expression tag |
Ser -13 | - | expression tag |
Ser -12 | - | expression tag |
Gly -11 | - | expression tag |
Leu -10 | - | expression tag |
Val -9 | - | expression tag |
Pro -8 | - | expression tag |
Arg -7 | - | expression tag |
Gly -6 | - | expression tag |
Ser -5 | - | expression tag |
His -4 | - | expression tag |
Met -3 | - | expression tag |
Ala -2 | - | expression tag |
Ser -1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 20736.7 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 1103.8 | |
All* | Total formula weight | 21840.5 |