6E3G

Structure of RORgt in complex with a novel agonist.

Summary for 6E3G

Entry DOI	10.2210/pdb6e3g/pdb
Descriptor	Nuclear receptor ROR-gamma, co-activator peptide, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywords	nuclear hormone receptor, agonist, nuclear protein, nuclear protein-agonist complex, nuclear protein/agonist
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	60229.96
Authors	Skene, R.J.,Hoffman, I. (deposition date: 2018-07-13, release date: 2019-06-12, Last modification date: 2024-03-13)
Primary citation	Yukawa, T.,Nara, Y.,Kono, M.,Sato, A.,Oda, T.,Takagi, T.,Sato, T.,Banno, Y.,Taya, N.,Imada, T.,Shiokawa, Z.,Negoro, N.,Kawamoto, T.,Koyama, R.,Uchiyama, N.,Skene, R.,Hoffman, I.,Chen, C.H.,Sang, B.,Snell, G.,Katsuyama, R.,Yamamoto, S.,Shirai, J. Design, Synthesis, and Biological Evaluation of Retinoic Acid-Related Orphan Receptor gamma t (ROR gamma t) Agonist Structure-Based Functionality Switching Approach from In House ROR gamma t Inverse Agonist to ROR gamma t Agonist. J.Med.Chem., 62:1167-1179, 2019 Cited by PubMed: 30652849 DOI: 10.1021/acs.jmedchem.8b01181 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation