6E0B
Plasmodium falciparum dihydroorotate dehydrogenase C276F mutant bound with triazolopyrimidine-based inhibitor DSM1
6E0B の概要
エントリーDOI | 10.2210/pdb6e0b/pdb |
関連するPDBエントリー | 3I65 3I68 3I6R |
分子名称 | Dihydroorotate dehydrogenase (quinone), mitochondrial, 5-methyl-7-(naphthalen-2-ylamino)-1H-[1,2,4]triazolo[1,5-a]pyrimidine-3,8-diium, FLAVIN MONONUCLEOTIDE, ... (7 entities in total) |
機能のキーワード | plasmodium falciparum, dihydroorotate dehydrogenase, triazolopyrimidine, inhibitor, dsm1, fad, flavoprotein, membrane, mitochondrion, mitochondrion inner membrane, oxidoreductase, pyrimidine biosynthesis, transit peptide |
由来する生物種 | Plasmodium falciparum (isolate 3D7) |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 46825.39 |
構造登録者 | |
主引用文献 | White, J.,Dhingra, S.K.,Deng, X.,El Mazouni, F.,Lee, M.C.S.,Afanador, G.A.,Lawong, A.,Tomchick, D.R.,Ng, C.L.,Bath, J.,Rathod, P.K.,Fidock, D.A.,Phillips, M.A. Identification and Mechanistic Understanding of Dihydroorotate Dehydrogenase Point Mutations in Plasmodium falciparum that Confer in Vitro Resistance to the Clinical Candidate DSM265. ACS Infect Dis, 5:90-101, 2019 Cited by PubMed: 30375858DOI: 10.1021/acsinfecdis.8b00211 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.099 Å) |
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