6E06

Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with cytidine triphosphate solved by precipitant-ligand exchange (crystals grown in citrate precipitant)

Summary for 6E06

Entry DOI	10.2210/pdb6e06/pdb
Related	3FGN 3FMF 3FMI 3FPA 4WOP 6CVE 6CVF 6CVU 6CVV 6CZB 6CZC 6CZD 6CZE 6E05
Descriptor	ATP-dependent dethiobiotin synthetase BioD, CYTIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... (4 entities in total)
Functional Keywords	enzyme, synthetase, nucleotide triphosphate binding, transferase
Biological source	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Total number of polymer chains	4
Total formula weight	95925.50
Authors	Thompson, A.P.,Wegener, K.L.,Bruning, J.B.,Polyak, S.W. (deposition date: 2018-07-06, release date: 2018-10-17, Last modification date: 2023-10-11)
Primary citation	Thompson, A.P.,Wegener, K.L.,Booker, G.W.,Polyak, S.W.,Bruning, J.B. Precipitant-ligand exchange technique reveals the ADP binding mode in Mycobacterium tuberculosis dethiobiotin synthetase. Acta Crystallogr D Struct Biol, 74:965-972, 2018 Cited by PubMed: 30289406 DOI: 10.1107/S2059798318010136 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation