6MVD

Crystal structure of Lecithin:cholesterol acyltransferase (LCAT) in complex with isopropyl dodec-11-enylfluorophosphonate (IDFP) and a small molecule activator

Replaces:  6DTJ

Summary for 6MVD

• Entry DOI: 10.2210/pdb6mvd/pdb
• Descriptor: Phosphatidylcholine-sterol acyltransferase, 2-acetamido-2-deoxy-beta-D-glucopyranose, propan-2-yl hydrogen (R)-ethylphosphonate, ... (7 entities in total)
• Functional Keywords: lcat, acyltransferase, cholesterol, activator, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 90375.54

Authors

Manthei, K.A.,Chang, L.,Tesmer, J.J.G. (deposition date: 2018-10-25, release date: 2018-12-05, Last modification date: 2023-10-11)

• Primary citation: Manthei, K.A.,Yang, S.M.,Baljinnyam, B.,Chang, L.,Glukhova, A.,Yuan, W.,Freeman, L.A.,Maloney, D.J.,Schwendeman, A.,Remaley, A.T.,Jadhav, A.,Tesmer, J.J.; Molecular basis for activation of lecithin:cholesterol acyltransferase by a compound that increases HDL cholesterol.; Elife, 7:-, 2018; PubMed: 30479275; DOI: 10.7554/eLife.41604

Experimental method

X-RAY DIFFRACTION (3.1 Å)