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6MVD

Crystal structure of Lecithin:cholesterol acyltransferase (LCAT) in complex with isopropyl dodec-11-enylfluorophosphonate (IDFP) and a small molecule activator

Replaces:  6DTJ
Functional Information from GO Data
ChainGOidnamespacecontents
A0003847molecular_function1-alkyl-2-acetylglycerophosphocholine esterase activity
A0004607molecular_functionphosphatidylcholine-sterol O-acyltransferase activity
A0004771molecular_functionsterol esterase activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0006629biological_processlipid metabolic process
A0006644biological_processphospholipid metabolic process
A0006656biological_processphosphatidylcholine biosynthetic process
A0008203biological_processcholesterol metabolic process
A0008374molecular_functionO-acyltransferase activity
A0016746molecular_functionacyltransferase activity
A0016787molecular_functionhydrolase activity
A0030301biological_processcholesterol transport
A0034186molecular_functionapolipoprotein A-I binding
A0034364cellular_componenthigh-density lipoprotein particle
A0034372biological_processvery-low-density lipoprotein particle remodeling
A0034375biological_processhigh-density lipoprotein particle remodeling
A0034435biological_processobsolete cholesterol esterification
A0042158biological_processlipoprotein biosynthetic process
A0042632biological_processcholesterol homeostasis
A0043691biological_processreverse cholesterol transport
A0046470biological_processphosphatidylcholine metabolic process
A0047179molecular_functionplatelet-activating factor acetyltransferase activity
A0070062cellular_componentextracellular exosome
A0090107biological_processregulation of high-density lipoprotein particle assembly
B0003847molecular_function1-alkyl-2-acetylglycerophosphocholine esterase activity
B0004607molecular_functionphosphatidylcholine-sterol O-acyltransferase activity
B0004771molecular_functionsterol esterase activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0006629biological_processlipid metabolic process
B0006644biological_processphospholipid metabolic process
B0006656biological_processphosphatidylcholine biosynthetic process
B0008203biological_processcholesterol metabolic process
B0008374molecular_functionO-acyltransferase activity
B0016746molecular_functionacyltransferase activity
B0016787molecular_functionhydrolase activity
B0030301biological_processcholesterol transport
B0034186molecular_functionapolipoprotein A-I binding
B0034364cellular_componenthigh-density lipoprotein particle
B0034372biological_processvery-low-density lipoprotein particle remodeling
B0034375biological_processhigh-density lipoprotein particle remodeling
B0034435biological_processobsolete cholesterol esterification
B0042158biological_processlipoprotein biosynthetic process
B0042632biological_processcholesterol homeostasis
B0043691biological_processreverse cholesterol transport
B0046470biological_processphosphatidylcholine metabolic process
B0047179molecular_functionplatelet-activating factor acetyltransferase activity
B0070062cellular_componentextracellular exosome
B0090107biological_processregulation of high-density lipoprotein particle assembly
Functional Information from PROSITE/UniProt
site_idPS00120
Number of Residues10
DetailsLIPASE_SER Lipases, serine active site. VFLIGHSLGC
ChainResidueDetails
AVAL175-CYS184

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Nucleophile => ECO:0000305|PubMed:26195816
ChainResidueDetails
ASER181
BSER181

site_idSWS_FT_FI2
Number of Residues4
DetailsACT_SITE: Charge relay system => ECO:0000305|PubMed:26195816
ChainResidueDetails
AASP345
AHIS377
BASP345
BHIS377

site_idSWS_FT_FI3
Number of Residues2
DetailsSITE: Determinant for substrate specificity => ECO:0000305|PubMed:14636062
ChainResidueDetails
AGLU149
BGLU149

site_idSWS_FT_FI4
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:26195816, ECO:0000269|PubMed:7613477, ECO:0007744|PDB:4X96
ChainResidueDetails
AASN84
AASN384
BASN84
BASN384

site_idSWS_FT_FI5
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:26195816, ECO:0000269|PubMed:7613477, ECO:0007744|PDB:4X96
ChainResidueDetails
AASN272
BASN272

221716

PDB entries from 2024-06-26

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