6MVD
Crystal structure of Lecithin:cholesterol acyltransferase (LCAT) in complex with isopropyl dodec-11-enylfluorophosphonate (IDFP) and a small molecule activator
Replaces: 6DTJEntity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Phosphatidylcholine-sterol acyltransferase | polymer | 383 | 43690.7 | 2 | UniProt (P04180) Pfam (PF02450) In PDB | Homo sapiens (Human) | Lecithin-cholesterol acyltransferase,Phospholipid-cholesterol acyltransferase |
2 | A, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 5 | Chemie (NAG) | |||
3 | A, B | propan-2-yl hydrogen (R)-ethylphosphonate | non-polymer | 152.1 | 2 | Chemie (H9A) | |||
4 | A, B | 6-{4-[(4R)-4-hydroxy-6-oxo-4-(trifluoromethyl)-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-b]pyridin-3-yl]piperidin-1-yl}-4-(trifluoromethyl)pyridine-3-carbonitrile | non-polymer | 474.4 | 2 | Chemie (H94) | |||
5 | A, B | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
6 | A | NICKEL (II) ION | non-polymer | 58.7 | 1 | Chemie (NI) | |||
7 | water | water | 18.0 | 20 | Chemie (HOH) |
Sequence modifications
A, B: 21 - 397 (UniProt: P04180)
PDB | External Database | Details |
---|---|---|
His 398 | - | expression tag |
His 399 | - | expression tag |
His 400 | - | expression tag |
His 401 | - | expression tag |
His 402 | - | expression tag |
His 403 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 87381.5 | |
Non-Polymers* | Number of molecules | 16 |
Total formula weight | 2994.1 | |
All* | Total formula weight | 90375.5 |