6DRS
Dihydrofolate Reductase (DHFR) of Aspergillus flavus in complex with a small molecule inhibitor
Summary for 6DRS
Entry DOI | 10.2210/pdb6drs/pdb |
Descriptor | Dihydrofolate reductase, putative, SULFATE ION, 3-{[(3R)-7,9-diamino-3-methyl-2,3-dihydrofuro[2,3-f]quinazolin-4-yl]oxy}benzonitrile, ... (5 entities in total) |
Functional Keywords | antifolate, dhfr, antifungal protein, antifungal protein-inhibitor complex, antifungal protein/inhibitor |
Biological source | Aspergillus flavus |
Total number of polymer chains | 1 |
Total formula weight | 29551.11 |
Authors | Bensen, D.C.,Fortier, J.M.,Akers-Rodriguez, S.,Tari, L.W. (deposition date: 2018-06-12, release date: 2019-06-19, Last modification date: 2023-10-11) |
Primary citation | Bensen, D.C.,Fortier, J.M.,Akers-Rodriguez, S.,Tari, L.W. Prospecting for broad-spectrum inhibitors of fungal dihydrofolate reductase using a structure guided approach. To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.997 Å) |
Structure validation
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