SPRY domain-containing SOCS box protein 2 complexed with (GZJ)VDINNN(CY3) Cyclic peptide inhibitor

Summary for 6DN8

Related PRD IDPRD_002312
DescriptorSPRY domain-containing SOCS box protein 4, (GZJ)VDINNN(CY3) Cyclic peptide inhibitor, ACETATE ION, ... (6 entities in total)
Functional Keywordsproteasomal degradation, nitric oxide, inhibitor, immune system, immune system-inhibitor complex, immune system/inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains6
Total molecular weight79262.02
Law, R.H.P.,Caradoc-Davies, T.T.,Norton, R.S. (deposition date: 2018-06-06, release date: 2019-04-17)
Primary citation
Sadek, M.M.,Barlow, N.,Leung, E.W.W.,Williams-Noonan, B.J.,Yap, B.K.,Shariff, F.M.,Caradoc-Davies, T.T.,Nicholson, S.E.,Chalmers, D.K.,Thompson, P.E.,Law, R.H.P.,Norton, R.S.
A Cyclic Peptide Inhibitor of the iNOS-SPSB Protein-Protein Interaction as a Potential Anti-Infective Agent.
ACS Chem. Biol., 13:2930-2938, 2018
PubMed: 30226743 (PDB entries with the same primary citation)
DOI: 10.1021/acschembio.8b00561
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.22120 0.8% 2.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6dn8
no rotation
Molmil generated image of 6dn8
rotated about x axis by 90°
Molmil generated image of 6dn8
rotated about y axis by 90°