6DJC

Crystal structure of human Bromodomain-containing protein 4 (BRD4) bromodomain with MS645

Summary for 6DJC

• Entry DOI: 10.2210/pdb6djc/pdb
• Descriptor: Bromodomain-containing protein 4, N,N'-(decane-1,10-diyl)bis{2-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetamide}, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: transcription, inhibitor, histone acetylation, transcription-inhibitor complex, transcription/inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 32808.81

Authors

Ren, C.,Zhou, M.M. (deposition date: 2018-05-25, release date: 2018-07-25, Last modification date: 2023-10-11)

• Primary citation: Ren, C.,Zhang, G.,Han, F.,Fu, S.,Cao, Y.,Zhang, F.,Zhang, Q.,Meslamani, J.,Xu, Y.,Ji, D.,Cao, L.,Zhou, Q.,Cheung, K.L.,Sharma, R.,Babault, N.,Yi, Z.,Zhang, W.,Walsh, M.J.,Zeng, L.,Zhou, M.M.; Spatially constrained tandem bromodomain inhibition bolsters sustained repression of BRD4 transcriptional activity for TNBC cell growth.; Proc. Natl. Acad. Sci. U.S.A., 115:7949-7954, 2018; PubMed: 30012592; DOI: 10.1073/pnas.1720000115

Experimental method

X-RAY DIFFRACTION (1.46 Å)