6DF7

TAF1-BD2 in complex with Cpd27 (6-(but-3-en-1-yl)-4-(1-methyl-6-(morpholine-4-carbonyl)-1H-benzo[d]imidazol-4-yl)-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one)

Summary for 6DF7

• Entry DOI: 10.2210/pdb6df7/pdb
• Related: 6DF4
• Descriptor: Transcription initiation factor TFIID subunit, 6-(but-3-en-1-yl)-4-[1-methyl-6-(morpholine-4-carbonyl)-1H-benzimidazol-4-yl]-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one (3 entities in total)
• Functional Keywords: taf1-bd2, bromodomain, small molecule inhibitor, sbdd, transcription-inhibitor complex, transcription/inhibitor
• Biological source: Oryctolagus cuniculus (Rabbit)
• Total number of polymer chains: 2
• Total formula weight: 39468.06

Authors

Murray, J.M. (deposition date: 2018-05-14, release date: 2018-11-14, Last modification date: 2023-10-11)

• Primary citation: Wang, S.,Tsui, V.,Crawford, T.D.,Audia, J.E.,Burdick, D.J.,Beresini, M.H.,Cote, A.,Cummings, R.,Duplessis, M.,Flynn, E.M.,Hewitt, M.C.,Huang, H.R.,Jayaram, H.,Jiang, Y.,Joshi, S.,Murray, J.,Nasveschuk, C.G.,Pardo, E.,Poy, F.,Romero, F.A.,Tang, Y.,Taylor, A.M.,Wang, J.,Xu, Z.,Zawadzke, L.E.,Zhu, X.,Albrecht, B.K.,Magnuson, S.R.,Bellon, S.,Cochran, A.G.; GNE-371, a Potent and Selective Chemical Probe for the Second Bromodomains of Human Transcription-Initiation-Factor TFIID Subunit 1 and Transcription-Initiation-Factor TFIID Subunit 1-like.; J. Med. Chem., 61:9301-9315, 2018; PubMed: 30289257; DOI: 10.1021/acs.jmedchem.8b01225

Experimental method

X-RAY DIFFRACTION (2 Å)