6DDY
Crystal structure of the double mutant (D52N/K359Q) of NT5C2-537X in the active state, Northeast Structural Genomics Target
6DDY の概要
エントリーDOI | 10.2210/pdb6ddy/pdb |
分子名称 | Cytosolic purine 5'-nucleotidase, PHOSPHATE ION, GLYCEROL, ... (4 entities in total) |
機能のキーワード | structural genomics, psi-biology, northeast structural genomics consortium, nesg, hydrolase |
由来する生物種 | Homo sapiens (Human) |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 64142.77 |
構造登録者 | Forouhar, F.,Dieck, C.L.,Tzoneva, G.,Carpenter, Z.,Ambesi-Impiombato, A.,Sanchez-Martin, M.,Kirschner-Schwabe, R.,Lew, S.,Seetharaman, J.,Ferrando, A.A.,Tong, L.,Northeast Structural Genomics Consortium (NESG) (登録日: 2018-05-10, 公開日: 2018-07-04, 最終更新日: 2023-10-11) |
主引用文献 | Dieck, C.L.,Tzoneva, G.,Forouhar, F.,Carpenter, Z.,Ambesi-Impiombato, A.,Sanchez-Martin, M.,Kirschner-Schwabe, R.,Lew, S.,Seetharaman, J.,Tong, L.,Ferrando, A.A. Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia. Cancer Cell, 34:136-147.e6, 2018 Cited by PubMed: 29990496DOI: 10.1016/j.ccell.2018.06.003 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.803 Å) |
構造検証レポート
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