6DDH

Crystal structure of the double mutant (D52N/R367Q) of NT5C2-537X in the active state, Northeast Structural Genomics Target

Summary for 6DDH

Entry DOI	10.2210/pdb6ddh/pdb
Descriptor	Cytosolic purine 5'-nucleotidase, INOSINIC ACID (3 entities in total)
Functional Keywords	structural genomics, psi-biology, northeast structural genomics consortium, nesg, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	64275.89
Authors	Forouhar, F.,Dieck, C.L.,Tzoneva, G.,Carpenter, Z.,Ambesi-Impiombato, A.,Sanchez-Martin, M.,Kirschner-Schwabe, R.,Lew, S.,Seetharaman, J.,Ferrando, A.A.,Tong, L.,Northeast Structural Genomics Consortium (NESG) (deposition date: 2018-05-10, release date: 2018-07-04, Last modification date: 2023-10-11)
Primary citation	Dieck, C.L.,Tzoneva, G.,Forouhar, F.,Carpenter, Z.,Ambesi-Impiombato, A.,Sanchez-Martin, M.,Kirschner-Schwabe, R.,Lew, S.,Seetharaman, J.,Tong, L.,Ferrando, A.A. Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia. Cancer Cell, 34:136-147.e6, 2018 Cited by PubMed: 29990496 DOI: 10.1016/j.ccell.2018.06.003 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.35 Å)

Structure validation