6DDH

Crystal structure of the double mutant (D52N/R367Q) of NT5C2-537X in the active state, Northeast Structural Genomics Target

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Cytosolic purine 5'-nucleotidase	polymer	554	63927.7	1	UniProt (P49902) Pfam (PF05761)	Homo sapiens (Human)	Cytosolic 5'-nucleotidase II
2	B (A)	INOSINIC ACID	non-polymer		348.2	1	Chemie (IMP)
3	C (A)	water	water		18.0	127	Chemie (HOH)

Sequence modifications

A: 1 - 536 (UniProt: P49902)

PDB	External Database	Details
Gly -17	-	expression tag
Ser -16	-	expression tag
Ser -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
Ser -8	-	expression tag
Ser -7	-	expression tag
Gly -6	-	expression tag
Leu -5	-	expression tag
Val -4	-	expression tag
Pro -3	-	expression tag
Arg -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag
Asn 52	Asp 52	engineered mutation
Gln 367	Arg 367	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	63927.7
Non-Polymers*	Number of molecules	1
	Total formula weight	348.2
All*	Total formula weight	64275.9

*Water molecules are not included.