Structure of the 50S ribosomal subunit from Methicillin Resistant Staphylococcus aureus in complex with the oxazolidinone antibiotic LZD-5

Summary for 6DDD

EMDB information7867 7870
Descriptor50S ribosomal protein L19, 50S ribosomal protein L2, 50S ribosomal protein L20, ... (28 entities in total)
Functional Keywordsantibiotic complex, linezolid, oxazolidinone, 50s, ribosome, ribosome-antibiotic complex, ribosome/antibiotic
Biological sourceStaphylococcus aureus
Total number of polymer chains27
Total molecular weight1306943.55
Belousoff, M.J.,Venugopal, H.,Bamert, R.S.,Lithgow, T. (deposition date: 2018-05-10, release date: 2019-03-20)
Primary citation
Belousoff, M.J.,Venugopal, H.,Wright, A.,Seoner, S.,Stuart, I.,Stubenrauch, C.,Bamert, R.S.,Lupton, D.W.,Lithgow, T.
cryoEM-Guided Development of Antibiotics for Drug-Resistant Bacteria.
ChemMedChem, 14:527-531, 2019
PubMed: 30667174 (PDB entries with the same primary citation)
DOI: 10.1002/cmdc.201900042
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliersRNA backbone160 0.6% 0.45MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures

More Asymmetric unit images

Molmil generated image of 6ddd
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Molmil generated image of 6ddd
rotated about x axis by 90°
Molmil generated image of 6ddd
rotated about y axis by 90°