6DDD

Structure of the 50S ribosomal subunit from Methicillin Resistant Staphylococcus aureus in complex with the oxazolidinone antibiotic LZD-5

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003735	molecular_function	structural constituent of ribosome
A	0005840	cellular_component	ribosome
A	0006412	biological_process	translation
A	0022625	cellular_component	cytosolic large ribosomal subunit
A	1990904	cellular_component	ribonucleoprotein complex
B	0002181	biological_process	cytoplasmic translation
B	0003723	molecular_function	RNA binding
B	0003735	molecular_function	structural constituent of ribosome
B	0005840	cellular_component	ribosome
B	0006412	biological_process	translation
B	0015934	cellular_component	large ribosomal subunit
B	0016740	molecular_function	transferase activity
B	0019843	molecular_function	rRNA binding
B	1990904	cellular_component	ribonucleoprotein complex
C	0000027	biological_process	ribosomal large subunit assembly
C	0003723	molecular_function	RNA binding
C	0003735	molecular_function	structural constituent of ribosome
C	0005840	cellular_component	ribosome
C	0006412	biological_process	translation
C	0019843	molecular_function	rRNA binding
C	0022625	cellular_component	cytosolic large ribosomal subunit
C	1990904	cellular_component	ribonucleoprotein complex
D	0003723	molecular_function	RNA binding
D	0003735	molecular_function	structural constituent of ribosome
D	0005737	cellular_component	cytoplasm
D	0005840	cellular_component	ribosome
D	0006412	biological_process	translation
D	0019843	molecular_function	rRNA binding
D	1990904	cellular_component	ribonucleoprotein complex
E	0003723	molecular_function	RNA binding
E	0003735	molecular_function	structural constituent of ribosome
E	0005840	cellular_component	ribosome
E	0006412	biological_process	translation
E	0015934	cellular_component	large ribosomal subunit
E	0019843	molecular_function	rRNA binding
E	0022625	cellular_component	cytosolic large ribosomal subunit
E	1990904	cellular_component	ribonucleoprotein complex
F	0003723	molecular_function	RNA binding
F	0003735	molecular_function	structural constituent of ribosome
F	0005840	cellular_component	ribosome
F	0006412	biological_process	translation
F	0019843	molecular_function	rRNA binding
F	0022625	cellular_component	cytosolic large ribosomal subunit
F	1990904	cellular_component	ribonucleoprotein complex
G	0003723	molecular_function	RNA binding
G	0003735	molecular_function	structural constituent of ribosome
G	0005840	cellular_component	ribosome
G	0006412	biological_process	translation
G	0019843	molecular_function	rRNA binding
G	0022625	cellular_component	cytosolic large ribosomal subunit
G	1990904	cellular_component	ribonucleoprotein complex
H	0003735	molecular_function	structural constituent of ribosome
H	0005840	cellular_component	ribosome
H	0006412	biological_process	translation
H	0008097	molecular_function	5S rRNA binding
I	0003735	molecular_function	structural constituent of ribosome
I	0005840	cellular_component	ribosome
I	0006412	biological_process	translation
I	0022625	cellular_component	cytosolic large ribosomal subunit
I	1990904	cellular_component	ribonucleoprotein complex
J	0003735	molecular_function	structural constituent of ribosome
J	0005840	cellular_component	ribosome
J	0006412	biological_process	translation
J	1990904	cellular_component	ribonucleoprotein complex
K	0003735	molecular_function	structural constituent of ribosome
K	0005840	cellular_component	ribosome
K	0006412	biological_process	translation
K	0022625	cellular_component	cytosolic large ribosomal subunit
K	1990904	cellular_component	ribonucleoprotein complex
L	0003723	molecular_function	RNA binding
L	0003735	molecular_function	structural constituent of ribosome
L	0005840	cellular_component	ribosome
L	0006412	biological_process	translation
L	0019843	molecular_function	rRNA binding
L	0022625	cellular_component	cytosolic large ribosomal subunit
L	1990904	cellular_component	ribonucleoprotein complex
M	0003735	molecular_function	structural constituent of ribosome
M	0005840	cellular_component	ribosome
M	0006412	biological_process	translation
M	0015934	cellular_component	large ribosomal subunit
M	0022625	cellular_component	cytosolic large ribosomal subunit
M	1990904	cellular_component	ribonucleoprotein complex
N	0003735	molecular_function	structural constituent of ribosome
N	0005840	cellular_component	ribosome
N	0006412	biological_process	translation
N	0015934	cellular_component	large ribosomal subunit
N	1990904	cellular_component	ribonucleoprotein complex
O	0003735	molecular_function	structural constituent of ribosome
O	0005737	cellular_component	cytoplasm
O	0005840	cellular_component	ribosome
O	0006412	biological_process	translation
O	1990904	cellular_component	ribonucleoprotein complex
P	0003735	molecular_function	structural constituent of ribosome
P	0005840	cellular_component	ribosome
P	0006412	biological_process	translation
Q	0003735	molecular_function	structural constituent of ribosome
Q	0005840	cellular_component	ribosome
Q	0006412	biological_process	translation
Q	0022625	cellular_component	cytosolic large ribosomal subunit
Q	1990904	cellular_component	ribonucleoprotein complex
R	0003735	molecular_function	structural constituent of ribosome
R	0005737	cellular_component	cytoplasm
R	0005840	cellular_component	ribosome
R	0006412	biological_process	translation
R	1990904	cellular_component	ribonucleoprotein complex
S	0003723	molecular_function	RNA binding
S	0003735	molecular_function	structural constituent of ribosome
S	0005840	cellular_component	ribosome
S	0006412	biological_process	translation
S	0019843	molecular_function	rRNA binding
S	1990904	cellular_component	ribonucleoprotein complex
V	0003729	molecular_function	mRNA binding
V	0003735	molecular_function	structural constituent of ribosome
V	0005840	cellular_component	ribosome
V	0006412	biological_process	translation
V	0017148	biological_process	negative regulation of translation
V	0022625	cellular_component	cytosolic large ribosomal subunit
V	1990904	cellular_component	ribonucleoprotein complex
W	0003723	molecular_function	RNA binding
W	0003735	molecular_function	structural constituent of ribosome
W	0005840	cellular_component	ribosome
W	0006412	biological_process	translation
W	0015934	cellular_component	large ribosomal subunit
W	0019843	molecular_function	rRNA binding
W	0022625	cellular_component	cytosolic large ribosomal subunit
W	0070180	molecular_function	large ribosomal subunit rRNA binding
W	1990904	cellular_component	ribonucleoprotein complex
X	0003723	molecular_function	RNA binding
X	0003735	molecular_function	structural constituent of ribosome
X	0005840	cellular_component	ribosome
X	0006412	biological_process	translation
X	0015934	cellular_component	large ribosomal subunit
X	0019843	molecular_function	rRNA binding
X	0022625	cellular_component	cytosolic large ribosomal subunit
X	1990904	cellular_component	ribonucleoprotein complex
Y	0000049	molecular_function	tRNA binding
Y	0003723	molecular_function	RNA binding
Y	0003735	molecular_function	structural constituent of ribosome
Y	0005840	cellular_component	ribosome
Y	0006412	biological_process	translation
Y	0019843	molecular_function	rRNA binding
Y	0022625	cellular_component	cytosolic large ribosomal subunit
Y	1990904	cellular_component	ribonucleoprotein complex
Z	0003735	molecular_function	structural constituent of ribosome
Z	0005840	cellular_component	ribosome
Z	0006412	biological_process	translation
Z	0022625	cellular_component	cytosolic large ribosomal subunit
Z	1990904	cellular_component	ribonucleoprotein complex
a	0003723	molecular_function	RNA binding
a	0003735	molecular_function	structural constituent of ribosome
a	0005737	cellular_component	cytoplasm
a	0005840	cellular_component	ribosome
a	0006412	biological_process	translation
a	0008097	molecular_function	5S rRNA binding
a	0019843	molecular_function	rRNA binding
a	0022625	cellular_component	cytosolic large ribosomal subunit
a	1990904	cellular_component	ribonucleoprotein complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue G6V 1 3001

Chain	Residue
1	G2088
1	A2089
1	A2478
1	C2479
1	A2530
1	U2531
1	G2532
1	U2533

---

Functional Information from PROSITE/UniProt

site_id	PS00049
Number of Residues	27
Details	RIBOSOMAL_L14 Ribosomal protein L14 signature. AVIVrtksgvrrn.DGsyikFdeNacVI

Chain	Residue	Details
W	ALA60-ILE86

---

site_id	PS00464
Number of Residues	25
Details	RIBOSOMAL_L22 Ribosomal protein L22 signature. KrfRpRAqGRasainkrtSHITIvV

Chain	Residue	Details
E	LYS83-VAL107

---

site_id	PS00467
Number of Residues	12
Details	RIBOSOMAL_L2 Ribosomal protein L2 signature. PtvRGSVmNPnD

Chain	Residue	Details
B	PRO218-ASP229

---

site_id	PS00474
Number of Residues	24
Details	RIBOSOMAL_L3 Ribosomal protein L3 signature. FvagdviDvtGvSkGKGfqGaikR

Chain	Residue	Details
L	PHE110-ARG133

---

site_id	PS00475
Number of Residues	31
Details	RIBOSOMAL_L15 Ribosomal protein L15 signature. KILGnGsLdkk..LtVkahkFSasAaeaIdakG

Chain	Residue	Details
X	LYS110-GLY140

---

site_id	PS00582
Number of Residues	20
Details	RIBOSOMAL_L33 Ribosomal protein L33 signature. YiTtKNkrnnPerVEmkKFC

Chain	Residue	Details
O	TYR17-CYS36

---

site_id	PS00586
Number of Residues	12
Details	RIBOSOMAL_L16_1 Ribosomal protein L16 signature 1. KRgGKVWIKIFP

Chain	Residue	Details
Y	LYS59-PRO70

---

site_id	PS00591
Number of Residues	11
Details	GH10_1 Glycosyl hydrolases family 10 (GH10) active site. AIEVdITELNI

Chain	Residue	Details
H	ALA140-ILE150

---

site_id	PS00701
Number of Residues	12
Details	RIBOSOMAL_L16_2 Ribosomal protein L16 signature 2. RMGaGKGavegW

Chain	Residue	Details
Y	ARG82-TRP93

---

site_id	PS00783
Number of Residues	23
Details	RIBOSOMAL_L13 Ribosomal protein L13 signature. IKGMLPstrl.GEkqgkkLfVYgG

Chain	Residue	Details
V	ILE106-GLY128

---

site_id	PS00784
Number of Residues	20
Details	RIBOSOMAL_L34 Ribosomal protein L34 signature. KRTYQpnkrkHskvh.GFrkR

Chain	Residue	Details
P	LYS3-ARG22

---

site_id	PS00828
Number of Residues	26
Details	RIBOSOMAL_L36 Ribosomal protein L36 signature. CekCkvIkRkgkVmViCenp.KHkQrQ

Chain	Residue	Details
R	CYS11-GLN36

---

site_id	PS00831
Number of Residues	15
Details	RIBOSOMAL_L27 Ribosomal protein L27 signature. GsILyRQRGtkiypG

Chain	Residue	Details
I	GLY42-GLY56

---

site_id	PS00936
Number of Residues	27
Details	RIBOSOMAL_L35 Ribosomal protein L35 signature. KTHrGAaKRVkrtasgqlkrsraft.SH

Chain	Residue	Details
Q	LYS5-HIS31

---

site_id	PS00937
Number of Residues	17
Details	RIBOSOMAL_L20 Ribosomal protein L20 signature. KrdfRkLWITRINaaaR

Chain	Residue	Details
C	LYS54-ARG70

---

site_id	PS01015
Number of Residues	16
Details	RIBOSOMAL_L19 Ribosomal protein L19 signature. VkRrGKVR.RAKLYYLR

Chain	Residue	Details
A	VAL88-ARG103

---

site_id	PS01108
Number of Residues	18
Details	RIBOSOMAL_L24 Ribosomal protein L24 signature. GDnVkVIaGkdKGke.GkV

Chain	Residue	Details
G	GLY6-VAL23

---

site_id	PS01167
Number of Residues	23
Details	RIBOSOMAL_L17 Ribosomal protein L17 signature. IeTTeaRaKevrsvvEkLITlGK

Chain	Residue	Details
Z	ILE30-LYS52

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI3
Number of Residues	93
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	40
Details	Compositional bias: {"description":"Basic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	10
Details	Compositional bias: {"description":"Gly residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---