6DC9

Fab/epitope complex of human chimeric monoclonal antibody h4E6 targeting a phosphorylated tau epitope.

6DC9 の概要

• エントリーDOI: 10.2210/pdb6dc9/pdb
• 分子名称: Fab heavy chain, Fab light chain, Microtubule-associated protein tau, ... (6 entities in total)
• 機能のキーワード: monoclonal antibody, fab, tau, phosphorylation state -specific antibody, immune system
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 100382.50

構造登録者

Chukwu, J.E.,Kong, X.-P. (登録日: 2018-05-04, 公開日: 2019-03-20, 最終更新日: 2019-12-18)

• 主引用文献: Chukwu, J.E.,Congdon, E.E.,Sigurdsson, E.M.,Kong, X.P.; Structural characterization of monoclonal antibodies targeting C-terminal Ser404region of phosphorylated tau protein.; MAbs, 11:477-488, 2019; PubMed: 30794086; DOI: 10.1080/19420862.2019.1574530

実験手法

X-RAY DIFFRACTION (2.999 Å)