6DAV
Crystal Structure of Human DHFR complexed with NADP and N10formyltetrahydrofolate
Summary for 6DAV
Entry DOI | 10.2210/pdb6dav/pdb |
Descriptor | Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N-(4-{[(2,4-diaminopteridin-6-yl)methyl](hydroxymethyl)amino}benzene-1-carbonyl)-L-glutamic acid, ... (5 entities in total) |
Functional Keywords | structure-guided drug discovery consortium, dihydrofolate reductase, hdhfr, nadp, oxidoreductase |
Biological source | Homo sapiens (Human) |
Cellular location | Mitochondrion : P00374 |
Total number of polymer chains | 2 |
Total formula weight | 45575.34 |
Authors | Mayclin, S.J.,Dranow, D.M.,Lorimer, D.D. (deposition date: 2018-05-02, release date: 2018-05-16, Last modification date: 2024-03-13) |
Primary citation | Mayclin, S.J.,Dranow, D.M.,Walpole, C.,Lorimer, D.D. Crystal Structure of Human DHFR complexed with NADP and N10formyltetrahydrofolate to be published, |
Experimental method | X-RAY DIFFRACTION (1.55 Å) |
Structure validation
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