6DAV
Crystal Structure of Human DHFR complexed with NADP and N10formyltetrahydrofolate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Dihydrofolate reductase | polymer | 187 | 21480.7 | 2 | UniProt (P00374) Pfam (PF00186) | Homo sapiens (Human) | |
| 2 | C, F (A, B) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 2 | Chemie (NAP) | |||
| 3 | D, G (A, B) | N-(4-{[(2,4-diaminopteridin-6-yl)methyl](hydroxymethyl)amino}benzene-1-carbonyl)-L-glutamic acid | non-polymer | 470.4 | 2 | Chemie (G3V) | |||
| 4 | E, H, I (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 5 | J, K (A, B) | water | water | 18.0 | 328 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 42961.4 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 2613.9 | |
| All* | Total formula weight | 45575.3 |
