6D78
The complex between high-affinity TCR DMF5(alpha-D26Y,beta-L98W) and human Class I MHC HLA-A2 with the bound MART-1(27-35)peptide
Summary for 6D78
Entry DOI | 10.2210/pdb6d78/pdb |
Descriptor | HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, Melanoma antigen recognized by T-cells 1, ... (6 entities in total) |
Functional Keywords | alpha-beta t-cell receptor bound to class i mhc (hla-a2) in complex with the mart-1 peptide, immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 5 |
Total formula weight | 93997.49 |
Authors | Hellman, L.M.,Singh, N.K. (deposition date: 2018-04-24, release date: 2019-04-03, Last modification date: 2023-10-04) |
Primary citation | Hellman, L.M.,Foley, K.C.,Singh, N.K.,Alonso, J.A.,Riley, T.P.,Devlin, J.R.,Ayres, C.M.,Keller, G.L.J.,Zhang, Y.,Vander Kooi, C.W.,Nishimura, M.I.,Baker, B.M. Improving T Cell Receptor On-Target Specificity via Structure-Guided Design. Mol. Ther., 27:300-313, 2019 Cited by PubMed: 30617019DOI: 10.1016/j.ymthe.2018.12.010 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.347 Å) |
Structure validation
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