6D78
The complex between high-affinity TCR DMF5(alpha-D26Y,beta-L98W) and human Class I MHC HLA-A2 with the bound MART-1(27-35)peptide
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | HLA class I histocompatibility antigen, A-2 alpha chain | polymer | 276 | 31985.4 | 1 | UniProt (P01892) Pfam (PF00129) Pfam (PF07654) UniProt (by SIFTS) (P04439) In PDB | Homo sapiens (Human) | MHC class I antigen A*2 |
2 | B | Beta-2-microglobulin | polymer | 100 | 11879.4 | 1 | UniProt (P61769) Pfam (PF07654) In PDB | Homo sapiens (Human) | |
3 | C | Melanoma antigen recognized by T-cells 1 | polymer | 9 | 814.0 | 1 | UniProt (Q16655) In PDB | Homo sapiens | MART-1, Antigen LB39-AA, Antigen SK29-AA, Protein Melan-A |
4 | D | DMF5 alpha chain,DMF5 alpha chain | polymer | 200 | 22186.5 | 1 | UniProt (K7N5M3) Pfam (PF07686) Pfam (PF09291) In PDB | Homo sapiens (Human) | |
5 | E | DMF5 beta chain,DMF5 beta chain | polymer | 243 | 27132.2 | 1 | UniProt (K7N5M4) Pfam (PF07686) Pfam (PF07654) In PDB | Homo sapiens (Human) | |
6 | water | water | 18.0 | 225 | Chemie (HOH) |
Sequence modifications
A: 1 - 275 (UniProt: P01892)
B: 1 - 99 (UniProt: P61769)
D: 0 - 110 (PDB: 6D78)
D: 111 - 199 (UniProt: K7N5M3)
E: 3 - 120 (PDB: 6D78)
E: 121 - 245 (UniProt: K7N5M4)
PDB | External Database | Details |
---|---|---|
Met 0 | - | initiating methionine |
PDB | External Database | Details |
---|---|---|
Met 0 | - | initiating methionine |
D: 111 - 199 (UniProt: K7N5M3)
E: 3 - 120 (PDB: 6D78)
E: 121 - 245 (UniProt: K7N5M4)
PDB | External Database | Details |
---|---|---|
Asp 204 | Asn 208 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 93997.5 | |
All* | Total formula weight | 93997.5 |