6D78

The complex between high-affinity TCR DMF5(alpha-D26Y,beta-L98W) and human Class I MHC HLA-A2 with the bound MART-1(27-35)peptide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	HLA class I histocompatibility antigen, A-2 alpha chain	polymer	276	31985.4	1	UniProt (P01892) Pfam (PF00129) Pfam (PF07654) UniProt (by SIFTS) (P04439)	Homo sapiens (Human)	MHC class I antigen A*2
2	B (B)	Beta-2-microglobulin	polymer	100	11879.4	1	UniProt (P61769) Pfam (PF07654)	Homo sapiens (Human)
3	C (C)	Melanoma antigen recognized by T-cells 1	polymer	9	814.0	1	UniProt (Q16655)	Homo sapiens	MART-1, Antigen LB39-AA, Antigen SK29-AA, Protein Melan-A
4	D (D)	DMF5 alpha chain,DMF5 alpha chain	polymer	200	22186.5	1	UniProt (K7N5M3) Pfam (PF07686) Pfam (PF09291)	Homo sapiens (Human)
5	E (E)	DMF5 beta chain,DMF5 beta chain	polymer	243	27132.2	1	UniProt (K7N5M4) Pfam (PF07686) Pfam (PF07654)	Homo sapiens (Human)
6	F, G, H, I, J (A, B, C, D, E)	water	water		18.0	225	Chemie (HOH)

Sequence modifications

A: 1 - 275 (UniProt: P01892)

PDB	External Database	Details
Met 0	-	initiating methionine

B: 1 - 99 (UniProt: P61769)

PDB	External Database	Details
Met 0	-	initiating methionine

D: 0 - 110 (PDB: 6D78)
D: 111 - 199 (UniProt: K7N5M3)
E: 3 - 120 (PDB: 6D78)
E: 121 - 245 (UniProt: K7N5M4)

PDB	External Database	Details
Asp 204	Asn 208	conflict

Sequence viewer

Contents of the asymmetric unit

*Water molecules are not included.