6D78

The complex between high-affinity TCR DMF5(alpha-D26Y,beta-L98W) and human Class I MHC HLA-A2 with the bound MART-1(27-35)peptide

Summary for 6D78

Entry DOI	10.2210/pdb6d78/pdb
Descriptor	HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, Melanoma antigen recognized by T-cells 1, ... (6 entities in total)
Functional Keywords	alpha-beta t-cell receptor bound to class i mhc (hla-a2) in complex with the mart-1 peptide, immune system
Biological source	Homo sapiens (Human) More
Total number of polymer chains	5
Total formula weight	93997.49
Authors	Hellman, L.M.,Singh, N.K. (deposition date: 2018-04-24, release date: 2019-04-03, Last modification date: 2023-10-04)
Primary citation	Hellman, L.M.,Foley, K.C.,Singh, N.K.,Alonso, J.A.,Riley, T.P.,Devlin, J.R.,Ayres, C.M.,Keller, G.L.J.,Zhang, Y.,Vander Kooi, C.W.,Nishimura, M.I.,Baker, B.M. Improving T Cell Receptor On-Target Specificity via Structure-Guided Design. Mol. Ther., 27:300-313, 2019 Cited by PubMed: 30617019 DOI: 10.1016/j.ymthe.2018.12.010 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.347 Å)

Structure validation