6D2P

Crystal structure of IOMA-class CLK31 Fab from an HIV-1 naive donor in complex with a germline-targeting gp120 engineered outer domain eOD-GT8 at 2.6 A

6D2P の概要

• エントリーDOI: 10.2210/pdb6d2p/pdb
• 分子名称: Germline-targeting HIV-1 gp120 engineered outer domain eOD-GT8, IOMAclass naive CLK31 Fab heavy chain, IOMAclass naive CLK31 Fab light chain, ... (5 entities in total)
• 機能のキーワード: hiv-1 gp120, engineered outer domain (eod), germline targeting, cd4 binding site, ioma-class naive human germline antibody, immune system, viral-protein complex, healthy hiv-1 negative donor
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 66465.18

構造登録者

Sarkar, A.,Wilson, I.A. (登録日: 2018-04-13, 公開日: 2019-01-16, 最終更新日: 2023-10-04)

• 主引用文献: Havenar-Daughton, C.,Sarkar, A.,Kulp, D.W.,Toy, L.,Hu, X.,Deresa, I.,Kalyuzhniy, O.,Kaushik, K.,Upadhyay, A.A.,Menis, S.,Landais, E.,Cao, L.,Diedrich, J.K.,Kumar, S.,Schiffner, T.,Reiss, S.M.,Seumois, G.,Yates, J.R.,Paulson, J.C.,Bosinger, S.E.,Wilson, I.A.,Schief, W.R.,Crotty, S.; The human naive B cell repertoire contains distinct subclasses for a germline-targeting HIV-1 vaccine immunogen.; Sci Transl Med, 10:-, 2018; PubMed: 29973404; DOI: 10.1126/scitranslmed.aat0381

実験手法

X-RAY DIFFRACTION (2.6 Å)