6D2P
Crystal structure of IOMA-class CLK31 Fab from an HIV-1 naive donor in complex with a germline-targeting gp120 engineered outer domain eOD-GT8 at 2.6 A
6D2P の概要
エントリーDOI | 10.2210/pdb6d2p/pdb |
分子名称 | Germline-targeting HIV-1 gp120 engineered outer domain eOD-GT8, IOMAclass naive CLK31 Fab heavy chain, IOMAclass naive CLK31 Fab light chain, ... (5 entities in total) |
機能のキーワード | hiv-1 gp120, engineered outer domain (eod), germline targeting, cd4 binding site, ioma-class naive human germline antibody, immune system, viral-protein complex, healthy hiv-1 negative donor |
由来する生物種 | Homo sapiens (Human) 詳細 |
タンパク質・核酸の鎖数 | 3 |
化学式量合計 | 66465.18 |
構造登録者 | |
主引用文献 | Havenar-Daughton, C.,Sarkar, A.,Kulp, D.W.,Toy, L.,Hu, X.,Deresa, I.,Kalyuzhniy, O.,Kaushik, K.,Upadhyay, A.A.,Menis, S.,Landais, E.,Cao, L.,Diedrich, J.K.,Kumar, S.,Schiffner, T.,Reiss, S.M.,Seumois, G.,Yates, J.R.,Paulson, J.C.,Bosinger, S.E.,Wilson, I.A.,Schief, W.R.,Crotty, S. The human naive B cell repertoire contains distinct subclasses for a germline-targeting HIV-1 vaccine immunogen. Sci Transl Med, 10:-, 2018 Cited by PubMed: 29973404DOI: 10.1126/scitranslmed.aat0381 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.6 Å) |
構造検証レポート
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