6D2I

JAK2 Pseudokinase V617F in complex with AT9283

Summary for 6D2I

• Entry DOI: 10.2210/pdb6d2i/pdb
• Descriptor: Tyrosine-protein kinase, 1-cyclopropyl-3-{3-[5-(morpholin-4-ylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl}urea (2 entities in total)
• Functional Keywords: kinase, pseudokinase domain, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 63300.74

Authors

Li, Q.,Li, K.,Eck, M.J. (deposition date: 2018-04-13, release date: 2019-03-20, Last modification date: 2023-10-04)

• Primary citation: McNally, R.,Li, Q.,Li, K.,Dekker, C.,Vangrevelinghe, E.,Jones, M.,Chene, P.,Machauer, R.,Radimerski, T.,Eck, M.J.; Discovery and Structural Characterization of ATP-Site Ligands for the Wild-Type and V617F Mutant JAK2 Pseudokinase Domain.; ACS Chem. Biol., 14:587-593, 2019; PubMed: 30763067; DOI: 10.1021/acschembio.8b00722

Experimental method

X-RAY DIFFRACTION (3.192 Å)