6D2I

JAK2 Pseudokinase V617F in complex with AT9283

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Tyrosine-protein kinase	polymer	273	31268.9	2	UniProt (Q506Q0) Pfam (PF07714) UniProt (by SIFTS) (O60674) In PDB	Homo sapiens (Human)
2	A, B	1-cyclopropyl-3-{3-[5-(morpholin-4-ylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl}urea	non-polymer		381.4	2	Chemie (35R)

Sequence modifications

A, B: 536 - 808 (UniProt: Q506Q0)

PDB	External Database	Details
Ala 659	Trp 659	engineered mutation
Ala 777	Trp 777	engineered mutation
His 794	Phe 794	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	62537.9
Non-Polymers*	Number of molecules	2
	Total formula weight	762.9
All*	Total formula weight	63300.7

*Water molecules are not included.