6D2I
JAK2 Pseudokinase V617F in complex with AT9283
Summary for 6D2I
Entry DOI | 10.2210/pdb6d2i/pdb |
Descriptor | Tyrosine-protein kinase, 1-cyclopropyl-3-{3-[5-(morpholin-4-ylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl}urea (2 entities in total) |
Functional Keywords | kinase, pseudokinase domain, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 63300.74 |
Authors | |
Primary citation | McNally, R.,Li, Q.,Li, K.,Dekker, C.,Vangrevelinghe, E.,Jones, M.,Chene, P.,Machauer, R.,Radimerski, T.,Eck, M.J. Discovery and Structural Characterization of ATP-Site Ligands for the Wild-Type and V617F Mutant JAK2 Pseudokinase Domain. ACS Chem. Biol., 14:587-593, 2019 Cited by PubMed: 30763067DOI: 10.1021/acschembio.8b00722 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.192 Å) |
Structure validation
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