6CZ4
Structure of the PTK6 kinase domain bound to a type II inhibitor 2-{[(3R,4S)-3-fluoro-1-{[4-(trifluoromethoxy)phenyl]acetyl}piperidin-4-yl]oxy}-5-(1-methyl-1H-imidazol-4-yl)pyridine-3-carboxamide
Summary for 6CZ4
Entry DOI | 10.2210/pdb6cz4/pdb |
Descriptor | Protein-tyrosine kinase 6, 2-{[(3R,4S)-3-fluoro-1-{[4-(trifluoromethoxy)phenyl]acetyl}piperidin-4-yl]oxy}-5-(1-methyl-1H-imidazol-4-yl)pyridine-3-carboxamide (3 entities in total) |
Functional Keywords | protein kinase, ptk6, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 30770.37 |
Authors | Gajiwala, K.S.,Johnson, E.,Cronin, C.N. (deposition date: 2018-04-07, release date: 2018-06-20, Last modification date: 2024-03-13) |
Primary citation | Qiu, L.,Levine, K.,Gajiwala, K.S.,Cronin, C.N.,Nagata, A.,Johnson, E.,Kraus, M.,Tatlock, J.,Kania, R.,Foley, T.,Sun, S. Small molecule inhibitors reveal PTK6 kinase is not an oncogenic driver in breast cancers. PLoS ONE, 13:e0198374-e0198374, 2018 Cited by PubMed: 29879184DOI: 10.1371/journal.pone.0198374 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
Download full validation report