6CZ4

Structure of the PTK6 kinase domain bound to a type II inhibitor 2-{[(3R,4S)-3-fluoro-1-{[4-(trifluoromethoxy)phenyl]acetyl}piperidin-4-yl]oxy}-5-(1-methyl-1H-imidazol-4-yl)pyridine-3-carboxamide

Summary for 6CZ4

Entry DOI	10.2210/pdb6cz4/pdb
Descriptor	Protein-tyrosine kinase 6, 2-{[(3R,4S)-3-fluoro-1-{[4-(trifluoromethoxy)phenyl]acetyl}piperidin-4-yl]oxy}-5-(1-methyl-1H-imidazol-4-yl)pyridine-3-carboxamide (3 entities in total)
Functional Keywords	protein kinase, ptk6, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	30770.37
Authors	Gajiwala, K.S.,Johnson, E.,Cronin, C.N. (deposition date: 2018-04-07, release date: 2018-06-20, Last modification date: 2024-03-13)
Primary citation	Qiu, L.,Levine, K.,Gajiwala, K.S.,Cronin, C.N.,Nagata, A.,Johnson, E.,Kraus, M.,Tatlock, J.,Kania, R.,Foley, T.,Sun, S. Small molecule inhibitors reveal PTK6 kinase is not an oncogenic driver in breast cancers. PLoS ONE, 13:e0198374-e0198374, 2018 Cited by PubMed: 29879184 DOI: 10.1371/journal.pone.0198374 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation