6CZ4
Structure of the PTK6 kinase domain bound to a type II inhibitor 2-{[(3R,4S)-3-fluoro-1-{[4-(trifluoromethoxy)phenyl]acetyl}piperidin-4-yl]oxy}-5-(1-methyl-1H-imidazol-4-yl)pyridine-3-carboxamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Protein-tyrosine kinase 6 | polymer | 264 | 30248.9 | 1 | UniProt (Q13882) Pfam (PF07714) | Homo sapiens (Human) | Breast tumor kinase,Tyrosine-protein kinase BRK |
| 2 | B (A) | 2-{[(3R,4S)-3-fluoro-1-{[4-(trifluoromethoxy)phenyl]acetyl}piperidin-4-yl]oxy}-5-(1-methyl-1H-imidazol-4-yl)pyridine-3-carboxamide | non-polymer | 521.5 | 1 | Chemie (FKY) | |||
| 3 | C (A) | water | water | 18.0 | 180 | Chemie (HOH) |
Sequence modifications
A: 182 - 443 (UniProt: Q13882)
| PDB | External Database | Details |
|---|---|---|
| Gly 180 | - | expression tag |
| Ser 181 | - | expression tag |
| Ala 184 | Trp 184 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 30248.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 521.5 | |
| All* | Total formula weight | 30770.4 |
