6CZ3

Structure of the PTK6 kinase domain bound to a type I inhibitor (3-fluoro-4-{[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino}phenyl)(morpholin-4-yl)methanone

6CZ3 の概要

• エントリーDOI: 10.2210/pdb6cz3/pdb
• 分子名称: Protein-tyrosine kinase 6, (3-fluoro-4-{[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino}phenyl)(morpholin-4-yl)methanone, ACETATE ION, ... (5 entities in total)
• 機能のキーワード: protein kinase, ptk6, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 31161.84

構造登録者

Gajiwala, K.S.,Johnson, E.,Cronin, C.N. (登録日: 2018-04-07, 公開日: 2018-06-20, 最終更新日: 2024-03-13)

• 主引用文献: Qiu, L.,Levine, K.,Gajiwala, K.S.,Cronin, C.N.,Nagata, A.,Johnson, E.,Kraus, M.,Tatlock, J.,Kania, R.,Foley, T.,Sun, S.; Small molecule inhibitors reveal PTK6 kinase is not an oncogenic driver in breast cancers.; PLoS ONE, 13:e0198374-e0198374, 2018; PubMed: 29879184; DOI: 10.1371/journal.pone.0198374

実験手法

X-RAY DIFFRACTION (1.8 Å)