6CYC

PDE2 in complex with compound 5

Summary for 6CYC

• Entry DOI: 10.2210/pdb6cyc/pdb
• Descriptor: cGMP-dependent 3',5'-cyclic phosphodiesterase, ZINC ION, MAGNESIUM ION, ... (6 entities in total)
• Functional Keywords: pde2, inhibition, structure-guided design, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 88960.34

Authors

Lu, J. (deposition date: 2018-04-05, release date: 2018-09-19, Last modification date: 2024-03-06)

• Primary citation: Stachel, S.J.,Berger, R.,Nomland, A.B.,Ginnetti, A.T.,Paone, D.V.,Wang, D.,Puri, V.,Lange, H.,Drott, J.,Lu, J.,Marcus, J.,Dwyer, M.P.,Suon, S.,Uslaner, J.M.,Smith, S.M.; Structure-Guided Design and Procognitive Assessment of a Potent and Selective Phosphodiesterase 2A Inhibitor.; ACS Med Chem Lett, 9:815-820, 2018; PubMed: 30128073; DOI: 10.1021/acsmedchemlett.8b00214

Experimental method

X-RAY DIFFRACTION (1.54 Å)