6CYC
PDE2 in complex with compound 5
Summary for 6CYC
Entry DOI | 10.2210/pdb6cyc/pdb |
Descriptor | cGMP-dependent 3',5'-cyclic phosphodiesterase, ZINC ION, MAGNESIUM ION, ... (6 entities in total) |
Functional Keywords | pde2, inhibition, structure-guided design, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 88960.34 |
Authors | |
Primary citation | Stachel, S.J.,Berger, R.,Nomland, A.B.,Ginnetti, A.T.,Paone, D.V.,Wang, D.,Puri, V.,Lange, H.,Drott, J.,Lu, J.,Marcus, J.,Dwyer, M.P.,Suon, S.,Uslaner, J.M.,Smith, S.M. Structure-Guided Design and Procognitive Assessment of a Potent and Selective Phosphodiesterase 2A Inhibitor. ACS Med Chem Lett, 9:815-820, 2018 Cited by PubMed: 30128073DOI: 10.1021/acsmedchemlett.8b00214 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.54 Å) |
Structure validation
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