6CXZ
RNA octamer containing 2'-F, 4'-Calpha-Me U.
Summary for 6CXZ
Entry DOI | 10.2210/pdb6cxz/pdb |
Related | 5VR4 |
Descriptor | RNA (5'-R(*CP*GP*AP*AP*(U4M)P*UP*CP*G)-3'), CACODYLATE ION, COBALT HEXAMMINE(III), ... (4 entities in total) |
Functional Keywords | rna, oligonucleotide, modified base |
Biological source | synthetic construct |
Total number of polymer chains | 2 |
Total formula weight | 5383.26 |
Authors | Harp, J.M.,Egli, M. (deposition date: 2018-04-04, release date: 2018-08-29, Last modification date: 2023-10-04) |
Primary citation | Harp, J.M.,Guenther, D.C.,Bisbe, A.,Perkins, L.,Matsuda, S.,Bommineni, G.R.,Zlatev, I.,Foster, D.J.,Taneja, N.,Charisse, K.,Maier, M.A.,Rajeev, K.G.,Manoharan, M.,Egli, M. Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity. Nucleic Acids Res., 46:8090-8104, 2018 Cited by PubMed: 30107495DOI: 10.1093/nar/gky703 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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