6CXZ

RNA octamer containing 2'-F, 4'-Calpha-Me U.

Summary for 6CXZ

• Entry DOI: 10.2210/pdb6cxz/pdb
• Related: 5VR4
• Descriptor: RNA (5'-R(*CP*GP*AP*AP*(U4M)P*UP*CP*G)-3'), CACODYLATE ION, COBALT HEXAMMINE(III), ... (4 entities in total)
• Functional Keywords: rna, oligonucleotide, modified base
• Biological source: synthetic construct
• Total number of polymer chains: 2
• Total formula weight: 5383.26

Authors

Harp, J.M.,Egli, M. (deposition date: 2018-04-04, release date: 2018-08-29, Last modification date: 2023-10-04)

• Primary citation: Harp, J.M.,Guenther, D.C.,Bisbe, A.,Perkins, L.,Matsuda, S.,Bommineni, G.R.,Zlatev, I.,Foster, D.J.,Taneja, N.,Charisse, K.,Maier, M.A.,Rajeev, K.G.,Manoharan, M.,Egli, M.; Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity.; Nucleic Acids Res., 46:8090-8104, 2018; PubMed: 30107495; DOI: 10.1093/nar/gky703

Experimental method

X-RAY DIFFRACTION (1.5 Å)