6CXL

anti-HIV-1 Fab 2G12 in complex with glycopeptide 10F5

Summary for 6CXL

Descriptoranti-HIV-1 Fab 2G12 light chain, anti-HIV-1 Fab 2G12 heavy chain, BETA-D-MANNOSE, ... (4 entities in total)
Functional Keywordsantibody, glycopeptide, hiv-1, glycobiology, immune system
Biological sourceHomo sapiens
Total number of polymer chains4
Total molecular weight97338.07
Authors
Stanfield, R.L.,Wilson, I.A. (deposition date: 2018-04-03, release date: 2019-02-20, Last modification date: 2019-03-20)
Primary citation
Nguyen, D.N.,Xu, B.,Stanfield, R.L.,Bailey, J.K.,Horiya, S.,Temme, J.S.,Leon, D.R.,LaBranche, C.C.,Montefiori, D.C.,Costello, C.E.,Wilson, I.A.,Krauss, I.J.
Oligomannose Glycopeptide Conjugates Elicit Antibodies Targeting the Glycan Core Rather than Its Extremities.
ACS Cent Sci, 5:237-249, 2019
PubMed: 30834312 (PDB entries with the same primary citation)
DOI: 10.1021/acscentsci.8b00588
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.586 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.24860 2.6% 0.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6cxl
no rotation
Molmil generated image of 6cxl
rotated about x axis by 90°
Molmil generated image of 6cxl
rotated about y axis by 90°