6CWY
Crystal structure of SUMO E1 in complex with an allosteric inhibitor
Summary for 6CWY
Entry DOI | 10.2210/pdb6cwy/pdb |
Descriptor | SUMO-activating enzyme subunit 1, SUMO-activating enzyme subunit 2, GLYCEROL, ... (8 entities in total) |
Functional Keywords | rossmann-like fold, ubiquitin-like fold, ubiquitin activating enzyme, activity, atp binding, ligase activity, atp/mg binding, ubiquitin e2, ligase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 113065.32 |
Authors | Lv, Z.,Yuan, L.,Atkison, J.H.,Williams, K.M.,Olsen, S.K. (deposition date: 2018-04-01, release date: 2019-01-16, Last modification date: 2023-10-04) |
Primary citation | Lv, Z.,Yuan, L.,Atkison, J.H.,Williams, K.M.,Vega, R.,Sessions, E.H.,Divlianska, D.B.,Davies, C.,Chen, Y.,Olsen, S.K. Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme. Nat Commun, 9:5145-5145, 2018 Cited by PubMed: 30514846DOI: 10.1038/s41467-018-07015-1 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.462 Å) |
Structure validation
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