6CWY
Crystal structure of SUMO E1 in complex with an allosteric inhibitor
Functional Information from GO Data
Chain | GOid | namespace | contents |
C | 0004839 | molecular_function | ubiquitin activating enzyme activity |
C | 0005515 | molecular_function | protein binding |
C | 0005634 | cellular_component | nucleus |
C | 0005654 | cellular_component | nucleoplasm |
C | 0005737 | cellular_component | cytoplasm |
C | 0008047 | molecular_function | enzyme activator activity |
C | 0008641 | molecular_function | ubiquitin-like modifier activating enzyme activity |
C | 0016567 | biological_process | protein ubiquitination |
C | 0016874 | molecular_function | ligase activity |
C | 0016925 | biological_process | protein sumoylation |
C | 0019948 | molecular_function | SUMO activating enzyme activity |
C | 0031510 | cellular_component | SUMO activating enzyme complex |
C | 0032446 | biological_process | protein modification by small protein conjugation |
C | 0033235 | biological_process | positive regulation of protein sumoylation |
C | 0036211 | biological_process | protein modification process |
C | 0043008 | molecular_function | ATP-dependent protein binding |
C | 0044388 | molecular_function | small protein activating enzyme binding |
C | 0046982 | molecular_function | protein heterodimerization activity |
C | 1903955 | biological_process | positive regulation of protein targeting to mitochondrion |
D | 0000166 | molecular_function | nucleotide binding |
D | 0000287 | molecular_function | magnesium ion binding |
D | 0005515 | molecular_function | protein binding |
D | 0005524 | molecular_function | ATP binding |
D | 0005634 | cellular_component | nucleus |
D | 0005654 | cellular_component | nucleoplasm |
D | 0005737 | cellular_component | cytoplasm |
D | 0008641 | molecular_function | ubiquitin-like modifier activating enzyme activity |
D | 0016740 | molecular_function | transferase activity |
D | 0016925 | biological_process | protein sumoylation |
D | 0019948 | molecular_function | SUMO activating enzyme activity |
D | 0031510 | cellular_component | SUMO activating enzyme complex |
D | 0032183 | molecular_function | SUMO binding |
D | 0033235 | biological_process | positive regulation of protein sumoylation |
D | 0044388 | molecular_function | small protein activating enzyme binding |
D | 0044390 | molecular_function | ubiquitin-like protein conjugating enzyme binding |
D | 0046872 | molecular_function | metal ion binding |
D | 0046982 | molecular_function | protein heterodimerization activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | binding site for residue GOL C 401 |
Chain | Residue |
C | HIS162 |
C | PRO288 |
C | PHE291 |
C | TYR294 |
site_id | AC2 |
Number of Residues | 6 |
Details | binding site for residue GOL C 402 |
Chain | Residue |
C | ILE115 |
C | VAL42 |
C | ASP67 |
C | HIS68 |
C | GLU69 |
C | ASP114 |
site_id | AC3 |
Number of Residues | 4 |
Details | binding site for residue ZN D 701 |
Chain | Residue |
D | CYS158 |
D | CYS161 |
D | CYS441 |
D | CYS444 |
site_id | AC4 |
Number of Residues | 4 |
Details | binding site for residue MG D 702 |
Chain | Residue |
D | ILE96 |
D | ASN98 |
D | TYR101 |
D | HIS124 |
site_id | AC5 |
Number of Residues | 6 |
Details | binding site for residue SO4 D 703 |
Chain | Residue |
D | ARG176 |
D | GLU205 |
D | PRO208 |
D | ASP209 |
D | ARG210 |
D | ALA211 |
site_id | AC6 |
Number of Residues | 5 |
Details | binding site for residue SO4 D 704 |
Chain | Residue |
D | ARG119 |
D | PRO165 |
D | THR166 |
D | ARG168 |
D | SER378 |
site_id | AC7 |
Number of Residues | 3 |
Details | binding site for residue SO4 D 705 |
Chain | Residue |
D | GLN74 |
D | LYS77 |
D | ALA91 |
site_id | AC8 |
Number of Residues | 3 |
Details | binding site for residue SO4 D 706 |
Chain | Residue |
D | PHE417 |
D | ASN419 |
D | VAL430 |
site_id | AC9 |
Number of Residues | 8 |
Details | binding site for residue FHJ D 707 |
Chain | Residue |
C | GLN79 |
D | CYS30 |
D | GLU31 |
D | LYS34 |
D | ALA76 |
D | SER79 |
D | VAL80 |
D | PHE83 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: Glycyl thioester intermediate => ECO:0000255|PROSITE-ProRule:PRU10132, ECO:0000269|PubMed:15660128, ECO:0000269|PubMed:20164921 |
Chain | Residue | Details |
D | CYS173 |
site_id | SWS_FT_FI2 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15660128 |
Chain | Residue | Details |
D | GLY24 | |
D | ASP48 | |
D | ASN56 | |
D | LYS72 | |
D | SER95 | |
D | ASP117 |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | BINDING: |
Chain | Residue | Details |
D | CYS158 | |
D | CYS161 | |
D | CYS441 | |
D | CYS444 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
D | SER207 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | MOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861 |
Chain | Residue | Details |
D | LYS271 |
site_id | SWS_FT_FI6 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
D | SER507 |
site_id | SWS_FT_FI7 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648 |
Chain | Residue | Details |
D | SER592 |
site_id | SWS_FT_FI8 |
Number of Residues | 1 |
Details | MOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:Q9Z1F9 |
Chain | Residue | Details |
D | LYS613 |
site_id | SWS_FT_FI9 |
Number of Residues | 1 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1) => ECO:0007744|PubMed:25114211 |
Chain | Residue | Details |
D | LYS164 |
site_id | SWS_FT_FI10 |
Number of Residues | 6 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) |
Chain | Residue | Details |
D | LYS190 | |
D | LYS275 | |
D | LYS611 | |
D | LYS617 | |
D | LYS623 |
site_id | SWS_FT_FI11 |
Number of Residues | 1 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25772364, ECO:0007744|PubMed:28112733 |
Chain | Residue | Details |
D | LYS236 |
site_id | SWS_FT_FI12 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733 |
Chain | Residue | Details |
D | LYS257 | |
D | LYS420 |
site_id | SWS_FT_FI13 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate |
Chain | Residue | Details |
D | LYS271 | |
D | LYS613 |
site_id | SWS_FT_FI14 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
Chain | Residue | Details |
D | LYS371 | |
D | LYS540 |