6CWY

Crystal structure of SUMO E1 in complex with an allosteric inhibitor

Entity

Chain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
CSUMO-activating enzyme subunit 1polymer34638499.81
UniProt (Q9UBE0)
Pfam (PF00899)
Homo sapiens (Human)Ubiquitin-like 1-activating enzyme E1A
DSUMO-activating enzyme subunit 2polymer66073485.91
UniProt (Q9UBT2)
Pfam (PF00899)
Pfam (PF14732)
Pfam (PF16195)
Homo sapiens (Human)Anthracycline-associated resistance ARX,Ubiquitin-like 1-activating enzyme E1B,Ubiquitin-like modifier-activating enzyme 2
GLYCEROLnon-polymer92.12
ZINC IONnon-polymer65.41
MAGNESIUM IONnon-polymer24.31
SULFATE IONnon-polymer96.14
dimethyl (1S,2S,3R,4R)-1-[(1S)-2-(4-methylphenyl)-1-(phenylamino)ethyl]-7-oxabicyclo[2.2.1]hept-5-ene-2,3-dicarboxylatenon-polymer421.51
waterwater18.045

Sequence viewer

Contents of the asymmetric unit

PolymersNumber of chains2
Total molecular weight111985.7
Non-Polymers*Number of molecules9
Total molecular weight1079.6
All*Total molecular weight113065.3
*Water molecules are not included.