6CS9
Crystal structure of human beta-defensin 2 in complex with PIP2
Summary for 6CS9
| Entry DOI | 10.2210/pdb6cs9/pdb |
| Descriptor | Beta-defensin 4A, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (3 entities in total) |
| Functional Keywords | antimicrobial, antifungal, defensin, innate defense, antimicrobial protein |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total formula weight | 10177.67 |
| Authors | Jarva, M.,Phan, K.,Lay, F.T.,Humble, C.,Hulett, M.,Kvansakul, M. (deposition date: 2018-03-20, release date: 2018-07-25, Last modification date: 2023-10-04) |
| Primary citation | Jarva, M.,Phan, T.K.,Lay, F.T.,Caria, S.,Kvansakul, M.,Hulett, M.D. Human beta-defensin 2 killsCandida albicansthrough phosphatidylinositol 4,5-bisphosphate-mediated membrane permeabilization. Sci Adv, 4:eaat0979-eaat0979, 2018 Cited by PubMed: 30050988DOI: 10.1126/sciadv.aat0979 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
Download full validation report
