6CQT

Crystal Structure of Recombinant Human Acetylcholinesterase Inhibited by (-) Stereoisomer of VX

Summary for 6CQT

• Entry DOI: 10.2210/pdb6cqt/pdb
• Related: 6CQU
• Descriptor: Acetylcholinesterase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 121346.63

Authors

Bester, S.M.,Guelta, M.A.,Pegan, S.D.,Height, J.J. (deposition date: 2018-03-16, release date: 2018-12-05, Last modification date: 2023-10-04)

• Primary citation: Bester, S.M.,Guelta, M.A.,Cheung, J.,Winemiller, M.D.,Bae, S.Y.,Myslinski, J.,Pegan, S.D.,Height, J.J.; Structural Insights of Stereospecific Inhibition of Human Acetylcholinesterase by VX and Subsequent Reactivation by HI-6.; Chem. Res. Toxicol., 31:1405-1417, 2018; PubMed: 30462502; DOI: 10.1021/acs.chemrestox.8b00294

Experimental method

X-RAY DIFFRACTION (2.273 Å)