6CMS
Closed structure of active SHP2 mutant E76K bound to SHP099 inhibitor
Summary for 6CMS
Entry DOI | 10.2210/pdb6cms/pdb |
Descriptor | Tyrosine-protein phosphatase non-receptor type 11, 6-(4-azanyl-4-methyl-piperidin-1-yl)-3-[2,3-bis(chloranyl)phenyl]pyrazin-2-amine (3 entities in total) |
Functional Keywords | protein tyrosine phosphatase, src homology domain 2, inactive state, active mutant, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 61357.15 |
Authors | Padua, R.A.P.,Sun, Y.,Marko, I.,Pitsawong, W.,Kern, D. (deposition date: 2018-03-06, release date: 2018-11-14, Last modification date: 2023-10-04) |
Primary citation | Padua, R.A.P.,Sun, Y.,Marko, I.,Pitsawong, W.,Stiller, J.B.,Otten, R.,Kern, D. Mechanism of activating mutations and allosteric drug inhibition of the phosphatase SHP2. Nat Commun, 9:4507-4507, 2018 Cited by PubMed: 30375376DOI: 10.1038/s41467-018-06814-w PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.68 Å) |
Structure validation
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