6CMS
Closed structure of active SHP2 mutant E76K bound to SHP099 inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein phosphatase non-receptor type 11 | polymer | 532 | 61004.9 | 1 | UniProt (Q06124) Pfam (PF00017) Pfam (PF00102) | Homo sapiens (Human) | Protein-tyrosine phosphatase 1D,PTP-1D,Protein-tyrosine phosphatase 2C,PTP-2C,SH-PTP2,Shp2,SH-PTP3 |
| 2 | B (A) | 6-(4-azanyl-4-methyl-piperidin-1-yl)-3-[2,3-bis(chloranyl)phenyl]pyrazin-2-amine | non-polymer | 352.3 | 1 | Chemie (5OD) | |||
| 3 | C (A) | water | water | 18.0 | 67 | Chemie (HOH) |
Sequence modifications
A: 1 - 529 (UniProt: Q06124)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Lys 76 | Glu 76 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 61004.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 352.3 | |
| All* | Total formula weight | 61357.1 |
