6CMN

Co-Crystal Structure of HIV-1 TAR Bound to Lab-Evolved RRM TBP6.7

Summary for 6CMN

Entry DOI	10.2210/pdb6cmn/pdb
Descriptor	TAR-Binding Protein 6.7, Trans-Activation Response RNA Element (3 entities in total)
Functional Keywords	protein-rna complex, tar rna, lab-evolved protein, arginine fork, beta hairpin, major-groove readout, base triple, u1a, hiv-1, trans-activation, rna recognition motif, rrm, rna binding protein-rna complex, rna binding protein/rna
Biological source	Oryctolagus cuniculus (Rabbit) More
Total number of polymer chains	2
Total formula weight	22383.00
Authors	Belashov, I.A.,Wedekind, J.E. (deposition date: 2018-03-05, release date: 2018-06-06, Last modification date: 2023-10-04)
Primary citation	Belashov, I.A.,Crawford, D.W.,Cavender, C.E.,Dai, P.,Beardslee, P.C.,Mathews, D.H.,Pentelute, B.L.,McNaughton, B.R.,Wedekind, J.E. Structure of HIV TAR in complex with a Lab-Evolved RRM provides insight into duplex RNA recognition and synthesis of a constrained peptide that impairs transcription. Nucleic Acids Res., 46:6401-6415, 2018 Cited by PubMed: 29961805 DOI: 10.1093/nar/gky529 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.796 Å)

Structure validation