6CMN

Co-Crystal Structure of HIV-1 TAR Bound to Lab-Evolved RRM TBP6.7

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	TAR-Binding Protein 6.7	polymer	119	13725.8	1	UniProt (G1TM83) Pfam (PF00076)	Oryctolagus cuniculus (Rabbit)
2	B (D)	Trans-Activation Response RNA Element	polymer	27	8657.2	1		Human immunodeficiency virus 1
3	C, D (A, D)	water	water		18.0	153	Chemie (HOH)

Sequence modifications

A: 1 - 98 (UniProt: G1TM83)

PDB	External Database	Details
Met -20	-	expression tag
Gly -19	-	expression tag
Ser -18	-	expression tag
Ser -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
Ser -10	-	expression tag
Ser -9	-	expression tag
Gly -8	-	expression tag
Glu -7	-	expression tag
Asn -6	-	expression tag
Leu -5	-	expression tag
Tyr -4	-	expression tag
Phe -3	-	expression tag
Gln -2	-	expression tag
Gly -1	-	expression tag
His 0	-	expression tag
Ser 19	Glu 19	engineered mutation
His 31	Tyr 31	engineered mutation
Arg 36	Gln 36	engineered mutation
Pro 46	Ser 46	engineered mutation
Gln 48	Ser 48	engineered mutation
Arg 49	Leu 49	engineered mutation
Thr 50	Lys 50	engineered mutation
Pro 51	Met 51	engineered mutation
Ala 83	Arg 83	engineered mutation
Lys 91	Ser 91	engineered mutation
Arg 92	Asp 92	engineered mutation
Pro 94	Ile 94	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	22383.0
All*	Total formula weight	22383.0

*Water molecules are not included.