6CLV

Staphylococcus aureus Dihydropteroate Synthase (saDHPS) F17L E208K double mutant structure

6CLV の概要

• エントリーDOI: 10.2210/pdb6clv/pdb
• 分子名称: Dihydropteroate synthase, 4-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}-N-(3,4-dimethyl-1,2-oxazol-5-yl)benzene-1-sulfonamide (3 entities in total)
• 機能のキーワード: antibiotic resistance mutations, sulfonamide resistance, antimicrobial protein
• 由来する生物種: Staphylococcus aureus
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 130955.10

構造登録者

Gajewski, S.,Griffith, E.C.,Wu, Y.,White, S.W. (登録日: 2018-03-02, 公開日: 2018-08-22, 最終更新日: 2024-03-13)

• 主引用文献: Griffith, E.C.,Wallace, M.J.,Wu, Y.,Kumar, G.,Gajewski, S.,Jackson, P.,Phelps, G.A.,Zheng, Z.,Rock, C.O.,Lee, R.E.,White, S.W.; The Structural and Functional Basis for Recurring Sulfa Drug Resistance Mutations inStaphylococcus aureusDihydropteroate Synthase.; Front Microbiol, 9:1369-1369, 2018; PubMed: 30065703; DOI: 10.3389/fmicb.2018.01369

実験手法

X-RAY DIFFRACTION (2.3 Å)