6CKR

Crystal Structure of BRD4 with QC4956

Summary for 6CKR

Entry DOI	10.2210/pdb6ckr/pdb
Descriptor	Bromodomain-containing protein 4, N-{3-[2-methyl-6-(1-methyl-1H-pyrazol-4-yl)-1-oxo-1,2-dihydroisoquinolin-4-yl]phenyl}methanesulfonamide (3 entities in total)
Functional Keywords	brd4, acetyllysine, epigenetics, gene regulation-inhibitor complex, gene regulation/inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Nucleus: O60885
Total number of polymer chains	2
Total formula weight	30841.55
Authors	Hosfield, D.J. (deposition date: 2018-02-28, release date: 2018-05-02, Last modification date: 2023-10-04)
Primary citation	Bennett, M.J.,Wu, Y.,Boloor, A.,Matuszkiewicz, J.,O'Connell, S.M.,Shi, L.,Stansfield, R.K.,Del Rosario, J.R.,Veal, J.M.,Hosfield, D.J.,Xu, J.,Kaldor, S.W.,Stafford, J.A.,Betancort, J.M. Design, synthesis and biological evaluation of novel 4-phenylisoquinolinone BET bromodomain inhibitors. Bioorg. Med. Chem. Lett., 28:1811-1816, 2018 Cited by PubMed: 29657099 DOI: 10.1016/j.bmcl.2018.04.016 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.62 Å)

Structure validation